Table 3.
Functional MRI results
| Contrast | Control > Cued | Untreated > Treated | ||||||
|---|---|---|---|---|---|---|---|---|
| Region | x y z | P(FWE) | K | Z | x y z | P(SVC) | K | Z |
| R anterior insular cortex | 42 23 −4 | <0.001 | 112 | 6.22 | 33 26 5 | 0.003 | 108 | 4.17 |
| R/L supplementary motor area | 0 8 56 | <0.001 | 271 | 6.85 | −3 5 65 | 0.082 | 163 | 3.25 |
| R dorsal anterior cingulate cortex | 9 20 35 | 5.74 | 3 20 44 | 0.022 | 3.67 | |||
| L dorsal anterior cingulate cortex | −6 20 38 | 5.55 | −6 17 35 | 0.944 | 1 | 1.68 | ||
| R inferior frontal gyrus (opercular) | 42 11 29 | <0.001 | 109 | 6.12 | 45 8 23 | 0.022 | 87 | 3.66 |
| R precentral gyrus | 48 8 44 | 5.02 | − | − | − | − | ||
| L inferior frontal gyrus (opercular) | −42 5 29 | <0.001 | 25 | 5.14 | − | − | − | − |
| L precentral gyrus | −45 5 38 | 4.92 | −45 5 38 | 0.007 | 25 | 3.98 | ||
| R middle temporal cortex | 60 −46 11 | 0.003 | 10 | 5.01 | − | − | − | − |
| Contrast | Cued > Control | Treated > Untreated | ||||||
| Region | x y z | P(unc.) | K | Z | x y z | P(FWE) | K | Z |
| R precuneus | 6 −55 29 | 0.003 | 4 | 2.70 | 6 −55 26 | <0.001 | 349 | 6.18 |
| L precuneus | − | − | − | − | −3 −58 41 | 5.78 | ||
| Contrast | Partial > Words | Initial > Final | ||||||
| Region | x y z | P(FWE) | K | Z | x y z | P(unc.) | K | Z |
| R anterior insular cortex | 33 26 2 | 0.004 | 9 | 4.93 | − | − | − | − |
| R inferior frontal gyrus (triangular) | 42 26 2 | 4.71 | − | − | − | − | ||
| L supplementary motor area | −3 8 56 | 0.003 | 11 | 5.06 | − | − | − | − |
| R caudate/putamen | 15 5 11 | <0.001 | 25 | 5.26 | − | − | − | − |
| Contrast | Words > Partial | Final > Initial | ||||||
| Region | x y z | P(FWE) | K | Z | x y z | P(unc.) | K | Z |
| R angular gyrus | 45 −52 32 | 0.004 | 9 | 4.87 | − | − | − | − |
| Contrast | Final > Words | Initial > Words | ||||||
| Region | x y z | P(FWE) | K | Z | x y z | P(unc.) | K | Z |
| R anterior insula | 33 23 2 | 0.012 | 4 | 4.68 | 33 26 2 | 0.001 | 225 | 3.84 |
| R inferior frontal cortex (triangular) | 48 26 17 | 0.020 | 2 | 4.77 | 45 26 5 | 3.36 | ||
| L supplementary motor area | −3 8 56 | <0.001 | 30 | 5.53 | −3 8 56 | 0.001 | 4 | 3.20 |
| R caudate/putamen | 15 5 11 | <0.001 | 29 | 5.46 | 15 5 11 | 0.001 | 225 | 3.66 |
| Contrast | Words > Final | Words > Initial | ||||||
| Region | x y z | P(FWE) | K | Z | x y z | P(unc.) | K | Z |
| R angular gyrus | 45 −55 32 | 0.028 | 1 | 4.73 | 51 −55 35 | 0.001 | 96 | 4.01 |
R = right; L = left; x y z = MNI coordinates; K = cluster size; Z = z-scores; FWE = family-wise error corrected P-values; SVC = small-volume corrected P-values within the volume of interest resulting from the contrast ‘Control > Cued'; unc. = uncorrected P-values (reported for completeness).