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Impact of miRNAs on GC biology. miRNAs modulate every aspect of GC biology, including the biosynthesis of GCs in the adrenal cortex, the localized conversion of cortisone to cortisol, the expression of the GC receptor, and its ability to respond to GC. Expression of miRNAs is also positively or negatively regulated by GCs as a means of bringing about changes in cell proliferation, survival, and function.
