Table 5.

Comparative Area Under the Receiver Operating Characteristic (AUROC) curves of different models using a binary outcome at week 8 (HIV-1 RNA reduction < or ≥ 1.5 log₁₀ copies/mL). All models include baseline CD4 and HIV-1 RNA and GSS of the accompanying drugs. The base model includes only baseline CD4 and HIV-1 RNA and GSS of the accompanying drugs. The final model includes the weighted mutations as listed in Table 3, the other models include a dummy variable indicating susceptibility or resistance according to the three existing interpretations systems (see Methods)

Models	AUROC	Difference in AUROC	P-value*	Difference in AUROC	P-value§
Subtype B = derivation set
Base model	0.804	ref
Final model	0.844	0.040	<0.001	ref
ANRS 2013	0.830	0.026	0.003	-0.014	0.108
HIVdb 7.0	0.824	0.020	0.002	-0.020	0.025
REGA 9.1.0	0.817	0.013	0.009	-0.027	0.002
subtype non-B = validation set
Base model	0.838	ref
Final model	0.872	0.034	0.015	ref
ANRS 2013	0.840	0.002	0.390	-0.032	0.016
HIVdb 7.0	0.840	0.001	0.690	-0.032	0.015
REGA 9.1.0	0.853	0.015	0.140	-0.019	0.190

^*comparison with the base model

^§comparison with the final model