Table 2.
The diagnostic test performance of neuropathy measures for distal symmetric polyneuropathy and small fiber predominant neuropathy.
| Variable | DSP AUC (95%CI) |
SFN AUC (95%CI) |
CAN AUC (95%CI) |
|---|---|---|---|
| NFD leg | 0.76 (0.64–0.87) | 0.82 (0.70–0.95) | 0.60 (0.47–0.73) |
| NFD thigh | 0.65 (0.52–0.79) | 0.67 (0.50–0.83) | 0.57 (0.45–0.70) |
| UENS* | 0.92 (0.85–1.00) | 0.96 (0.90–1.00) | 0.70 (0.53–0.86) |
| Valsalva ratio | 0.55 (0.43–0.67) | 0.52 (0.36–0.67) | Part of definition |
| E:I ratio | 0.68 (0.56–0.80) | 0.61 (0.45–0.76) | Part of definition |
| 30:15 ratio | 0.64 (0.53–0.75) | 0.63 (0.49–0.78) | Part of definition |
| MHR | 0.54 (0.42–0.67) | 0.57 (0.42–0.72) | 0.58 (0.44–0.73) |
| LFA | 0.50 (0.37–0.64) | 0.48 (0.30–0.65) | 0.42 (0.29–0.55) |
| RFA | 0.38 (0.25–0.50) | 0.37 (0.22–0.53) | 0.34 (0.21–0.47) |
| LFA/RFA ratio | 0.62 (0.50–0.75) | 0.55 (0.40–0.69) | 0.63 (0.52–0.75) |
| sdNN | 0.60 (0.46–0.73) | 0.49 (0.32–0.67) | 0.65 (0.52–0.77) |
| rmsSD | 0.60 (0.48–0.71) | 0.45 (0.30–0.60) | 0.66 (0.54–0.79) |
| Sudoscan feet* | 0.68 (0.51–0.84) | 0.77 (0.58–0.96) | 0.61 (0.42–0.79) |
| Sudoscan hands* | 0.56 (0.39–0.72) | 0.57 (0.40–0.75) | 0.53 (0.35–0.71) |
| QSART foot | 0.48 (0.35–0.61) | 0.57 (0.41–0.74) | 0.45 (0.32–0.59) |
| QSART distal leg | 0.54 (0.41–0.68) | 0.52 (0.35–0.68) | 0.50 (0.37–0.63) |
| QSART proximal leg | 0.51 (0.38–0.64) | 0.48 (0.32–0.65) | 0.52 (0.40–0.65) |
| QSART arm | 0.66 (0.55–0.77) | 0.70 (0.58–0.81) | 0.48 (0.33–0.63) |
| QST cold | 0.64 (0.51–0.78) | 0.67 (0.52–0.83) | 0.60 (0.46–0.74) |
| QST vibration | 0.71 (0.60–0.81) | ||
| Sural amplitude | 0.65 (0.52–0.79) | ||
| Sural PL | 0.68 (0.55–0.81) | ||
| Peroneal amplitude | 0.63 (0.51–0.76) | ||
| Peroneal DML | 0.75 (0.64–0.86) | ||
| Peroneal CV | 0.66 (0.53–0.80) | ||
| Peroneal F response | 0.73 (0.62–0.84) | ||
| Tibial amplitude | 0.73 (0.60–0.86) | ||
| Tibial DML | 0.67 (0.55–0.78) | ||
| Tibial F response | 0.76 (0.65–0.87) | ||
| Ulnar sensory amplitude | 0.73 (0.63–0.84) | ||
| Ulnar sensory PL | 0.58 (0.46–0.70) | ||
| Median sensory amplitude | 0.68 (0.56–0.80) | ||
| Median sensory PL | 0.57 (0.44–0.70) | ||
| Median motor amplitude | 0.47 (0.33–0.60) | ||
| Median motor DML | 0.54 (0.41–0.68) | ||
| Median motor CV | 0.56 (0.43–0.69) | ||
| Median F response | 0.36 (0.23–0.49) | ||
| MNSI Questionnaire | 0.75 (0.63–0.86) | ||
| MNSI Examination | 0.81 (0.71–0.91) | ||
| MNSI Reduced Combined index | 0.86 (0.78–0.93) | ||
| Monofilament | 0.67 (0.57–0.77) | ||
| Neurothesiometer** | 0.72 (0.54–0.89) |
The Sudoscan was only performed on 70 participants.
The Neurothesiometer and UENS were only performed on 61 and 62 participants respectively.
DSP= distal symmetric polyneuropathy, SFN= small fiber neuropathy, CAN=cardiovascular autonomic neuropathy, AUC=area under the curve, NFD=nerve fiber density, PL=peak latency, DML=distal motor latency, CV=conduction velocity, QSART=quantitative sudomotor axonal reflex testing, QST=quantitative sensory testing, MNSI-Michigan Neuropathy Screening Instrument, UENS=Utah Early Neuropathy Scale, E:I=Expiration, Inspiration, MHR=mean heart rate, LFA= low frequency area, RFA= respiratory frequency area, sdNN= standard deviation of the normal to normal interval, rmsSD= root mean square of successive differences of the normal to normal interval.