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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Mol Neurobiol. 2018 Jan;55(1):164–172. doi: 10.1007/s12035-017-0730-0

Figure 2. The timeline of the experimental design and the IPB morphometry in mice.

Figure 2

A Ketamine exposure occurred at post-natal day (PND) 7 when synaptogenesis is at the peak in mice. The IPB length was measured at different age points - when IPB length is about maximal (PND10); IPB length begins to decrease (PNDs 20 and 30) and IPB length reaches its final length (PNDs 40 and 65).

B. The morphometric approach used to evaluate so called ‘normalized length of IPB’, which takes into consideration individual variability and developmental growth of hippocampus. The IPB length was approximated from the tip of the inferior blade of the dentate granule cell layer (“a”). The length of CA3 was approximated from the tip of the inferior blade to the apex of the curvature of the CA3 pyramidal cell layer (“b”). Normalized IPB length was taken as a ratio between “a” and “b”.