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Cathepsin L and the replicative lifespan. A mother cell specific lifespan with the strain BY4741 was performed using a singer micromanipulator (a). Transformation of BY4741 with the two plasmid YCplac111–HOprom.‐GFP p416GPD (continuous line; diamonds) leads to a decreased replicative lifespan that increases greatly and significantly (p‐value <0.001) upon expression of cathepsin L (p416GPD‐cathepsin L) (dotted lines; triangles)
