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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Chem Rev. 2015 Feb 18;115(7):2483–2531. doi: 10.1021/cr500537t

Figure 16.

Figure 16

Real-time detection of cancer marker, HER2, using a graphene-encapsulated nanoparticle-based FET biosensor. (A) The preparation of the rGO–NP device. (B) Surface functionalization of rGO for immobilizing the antibody. (C) Measuring conductance of the devices when the target protein is introduced. (D) The sensitivity of the biosensor (relative conductance change, %) in response to the concentration of HER2 with VDS (voltage drain to source) = 1 V and Vg (gate voltage) = 0 V. (E) The selectivity of the biosensor in response to PBS buffer, BSA with 50 μg mL−1, and HER2 (100 pM and 1 μM). (F) Sensor sensitivity (relative conductance change, %) as a function of the HER2 concentration with VDS = 1 V and Vg = 0 V. All experiments were performed multiple times (sample number, n = 30) to collect statistical data (with error bars) and confirm the reproducibility and robustness of the biosensing system. Reprinted with permission from ref 101b. Copyright 2011 Wiley.