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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Chem Rev. 2015 Feb 18;115(7):2483–2531. doi: 10.1021/cr500537t

Figure 24.

Figure 24

DNA-templated silver nanoclusters–GO hybrids for the detection of multiple nucleic acids. (A) Schematic representation of the preparation of silver nanoclusters on DNA scaffolds in aqueous solution. (B) Schematic illustration of the assay for label-free DNA detection using AgNCs–GO nanohybrid materials. (C) Fluorescence emission spectra of P1 (1 mM) upon addition of T1 with different concentrations: (a) control; (b) 1 nM; (c) 5 nM; (d) 10 nM; (e) 50 nM; (f) 100 nM; (g) 300 nM; (h) 600 nM; (i) 800 nM; and (j) 1000 nM, which was then quenched with GO. Inset: A zoomed-in view of the data for low concentrations of target (a–e). (D) Linear relationship between (F − F0)/F0 (relative fluorescence intensity, where F0 and F are the fluorescence intensities without and with the presence of target DNA, respectively) and the concentration of target DNA (1–1000 nM). Error bars were obtained from three parallel experiments. Reprinted with permission from ref 165. Copyright 2012 Royal Society of Chemistry.