GO–AuNP hybrid-based SERS probe for cancer cell imaging. (A) Scheme for the preparation of GO and Au nanoparticle decorated GO (Au/GO hybrids). Optical (B, D, F, H) and Raman (C, E, G, I) images of HeLa 229 cells. Cells were incubated in medium without GO (B and C), in medium with Au nanoparticles (D and E), in medium with GO (F and G), and Au/GO hybrids (H and I). Scale bars: 10 μm. Reprinted with permission from ref 197. Copyright 2012 Royal Society of Chemistry.