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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Chem Rev. 2015 Feb 18;115(7):2483–2531. doi: 10.1021/cr500537t

Figure 35.

Figure 35

Multifunctional chitosan magnetic-graphene nanoparticles for tumor-targeted codelivery of drugs, genes, and MRI contrast agents. (A) Schematic showing the generation of DOX-loaded chitosan functionalized magnetic graphene complexed with DNA plasmids encoding GFP (DOX-CMG-GFP-DNA) complexes. (B) GFP expression and DOX fluorescence in frozen sections from mice injected with DOX-CMG-GFP-DNA (30 μg of DOX and 25 μg of GFP-DNA), examined using a fluorescent microscope at 400× magnification. Expression was quantified and normalized to control background. Reprinted with permission from ref 228. Copyright 2013 Royal Society of Chemistry.