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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Chem Rev. 2015 Feb 18;115(7):2483–2531. doi: 10.1021/cr500537t

Figure 36.

Figure 36

rGO/carbon/mesoporous silica nanocookies for NIR-triggered photochemothermal therapy. (A) Schematic illustration of chemo-photothermal therapy using reduced graphene oxide/carbon/mesoporous silica nanocookies, under NIR light-control. (B) FE-SEM and (C) low magnification TEM images of nanocookies. Inset: High magnification images of a nanocookie. (D) Infrared thermal images of a MDA-MB-231 tumor-bearing nude mouse treated with PBS+NIR (control), CPT+NIR, nanocookie-CPT (no NIR), nanocookie+NIR, nanocookie-CPT+NIR treatment. Color bar on right shows temperature in °C. Pictures at day 4 after NIR irradiation (808 nm, 0.75 W cm−2, 5 min, 1 min interval for every min treatment) show the tumor turned into a scab at the site injected with nanocookie+NIR and nanocookie-CPT+NIR. White circles represent tumor sites. (E) Changes in body weight and tumor volumes following treatment. Reprinted with permission from ref 238. Copyright 2014 Wiley.