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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Proteomics Clin Appl. 2013 Sep 9;7(9-10):618–631. doi: 10.1002/prca.201300024

Figure 3.

Figure 3

Tn and STn antigens on blood cells in Tn syndrome. Tn syndrome is a rare autoimmune disorder in which populations of blood cells from all lineages express Tn antigen. Genetic/epigenetic alterations in Cosmc in an early blood progenitor result in Tn expression and associated pathology, including hemolytic anemia, thrombocytopenia, and bleeding disorders. Pathology is thought to be due to formation of anti-Tn IgM antibodies and/or dysfunction of O-glycosylated proteins found on blood cells. A targeted deletion of Cosmc in murine endothelial/hematopoietic cells was recently observed to result in macrothrombocytopenia, prolonged tail-bleeding times, and dysregulation of multiple platelet integrins.