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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Acc Chem Res. 2015 Dec 14;49(1):17–26. doi: 10.1021/acs.accounts.5b00345

Figure 1.

Figure 1

Magnetic core−shell nanoparticles (MCNPs) efficiently deliver siRNA into rNSCs. (a) MCNPs were functionalized to complex negatively charged siRNA. (b) Transmission electron microscopy image of MCNPs. Scale bar: 10 nm. (c) MCNPs dispersed in water are attracted to a magnet. (d) Magnetically facilitated delivery of siRNA to induce neural differentiation of rNSCs using MCNPs. Fluorescence images depict (top) neuronal and (bottom) oligodendrocyte differentiation after siSOX9 and siCAV delivery, respectively. Adapted with permission from ref 14. Copyright 2013 Wiley.