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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Acc Chem Res. 2015 Dec 14;49(1):17–26. doi: 10.1021/acs.accounts.5b00345

Figure 2.

Figure 2

DexAM facilitates codelivery of siRNA and hydrophobic small molecules into rNSCs. (a) DexAM comprises a positively charged polyamine backbone to complex negatively charged siRNA and a β-cyclodextrin moiety to encapsulate small-molecule drugs. (b) Complexed DexAM constructs were delivered to rNSCs to enhance neuronal differentiation. (c) Fluorescence images of cells stained for the neuronal marker TuJ1 and the astrocytic marker GFAP. Scale bars: 20 μm. (d) Plot showing quantification of the stained cells. Statistical significance is compared to RA−siSOX9 treatment (*, p < 0.001). Adapted from ref 17. Copyright 2013 American Chemical Society.