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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Acc Chem Res. 2015 Dec 14;49(1):17–26. doi: 10.1021/acs.accounts.5b00345

Figure 4.

Figure 4

Patterned nanosized graphene oxide (NGO) induces neuronal differentiation of human adipose-derived mesenchymal stem cells (hADMSCs). (a) hADMSCs cultured on grid patterns of NGO facilitated differentiation into neuronal cells. (b) Images of hADMSCs grown on poly(L-lysine) (PLL)-coated Au (Au), NGO-coated Au (Au-NGO), and NGO grid-patterned substrates [Au-NGO (Grid)]. Scale bars: 20 μm. (c) Plot showing quantification of the percentage of cells expressing the neuronal marker TuJ1 (*, p < 0.01). (d) Images of cells stained for F-actin (green) and nucleus (blue) showing extensive cellular extension on NGO grid patterns. Scale bar: 50 μm. (e) Plot showing quantification of the length of cellular extension on various substrates (*, p < 0.01). Adapted from ref 30. Copyright 2015 American Chemical Society.