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Compounds with disulfide bonds introduced by fungal and bacterial sulfhydryl oxidases related to the thioredoxin reductase enzyme family. Gliotoxin is a epipolythiodioxopiperazine virulence factor in Aspergillus. Holomycin is a broad-spectrum antibiotic from Streptomyces. Romidepsin (FK228) is a depsipeptide anticancer agent from Chromobacterium species used against T-cell lymphomas.
