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. Author manuscript; available in PMC: 2019 Feb 14.
Published in final edited form as: Chem Rev. 2017 Jul 12;118(3):1169–1198. doi: 10.1021/acs.chemrev.7b00123

Figure 5.

Figure 5

Mechanism of disulfide bond formation by 1,4-quinones. Attack of a thiolate on quinone (1) forms the Michael adduct (2) which can be resolved as in (3) to generate the reduced cofactor and the corresponding disulfide, RS-SR.