Table 2.
Resting and post-mental stress values of inflammatory biomarkers (MIPS Study).
| Rest | Post stress | Unadjusted
|
Adjusted Model 1**
|
Adjusted Model 2†
|
Adjusted Model 3‡
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | β (95 % CI) | P value* | β (95 % CI) | P value* | β (95 % CI) | P value* | β (95 % CI) | P value* | |
| IL-6, pg/mL | 1.4 (1.0–2.1) |
1.7 (1.2–2.6) |
0.33 (0.29, 0.38) |
<0.0001 | 0.34 (0.29, 0.39) |
<0.0001 | 0.34 (0.29, 0.39) |
<0.0001 | 0.32 (0.28, 0.37) |
<0.0001 |
| MCP-1, pg/mL | 123.1 (102.1–147.5) |
128.3 (106.7–155.3) |
0.07 (0.05, 0.09) |
<0.0001 | 0.07 (0.05, 0.09) |
<0.0001 | 0.07 (0.05, 0.09) |
<0.0001 | 0.07 (0.05, 0.09) |
<0.0001 |
| MMP-9, ng/mL | 61.5 (41.5–96.7) |
68.6 (46.2–98.7) |
0.13 (0.09, 0.17) |
<0.0001 | 0.13 (0.09, 0.17) |
<0.0001 | 0.13 (0.09, 0.18) |
<0.0001 | 0.13 (0.09, 0.18) |
<0.0001 |
| hsCRP, mg/L | 1.6 (0.6–3.8) |
1.4 (0.6–3.6) |
−0.03 (−0.06, 0.002) |
0.03 | −0.03 (−0.06, 0.0003) |
0.05 | −0.02 (−0.05, 0.01) |
0.11 | −0.02 (−0.05, 0.01) |
0.22 |
Abbreviations: IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; MMP-9, matrix metallopeptidase 9; HsCRP, high-sensitivity C reactive protein. A log 2 transformation was used for biomarker values in the analysis.
*
p values were obtained from repeated measures model.
**
Adjusted model 1: Adjusted for age, sex, African American race, body mass index, smoking, diabetes, hypertension, beck depression inventory score, and previous myocardial infarction.
†
Adjusted model 2: Adjusted model 1 + accounting for biomarker plate as a random effect.
‡
Adjusted model 3: Adjusted model 2 + adjusting for sequence of mental/physical stress.