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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Nature. 2017 Mar 22;543(7647):723–727. doi: 10.1038/nature21433

Fig. 3. MHC-I and MHC-II presentation of lymphoma immunoglobulins.

Fig. 3

(a) Heat-map reflects the frequency and distribution of MHC-I (left) and MHC-II (right) presentation of IgM-derived peptides across the cohort. Panels (b) and (c) depict expanded views of antigen presentation from variable regions of Ig heavy and kappa light chains, respectively. Neoantigen peptides created by either somatic hypermutation or VDJ rearrangement are aligned to expanded heat-maps, and grouped by patient (boxes). Red, somatically mutated positions within recovered peptides creating neoantigens. Asterisks, patients/peptides selected for subsequent functional immunological studies.