Table 2.
Key parameters in the agent-based model.
Parameter | % | Vaccine received (%)
|
Range
|
Reference | ||||
---|---|---|---|---|---|---|---|---|
LAIV | IIV-IM | IIV-ID | No. | Minimum | Maximum | |||
Coverage by age, years | ||||||||
6–23 months | 70.4 | 0.0 | 100.0 | 0.0 | 69.6 | 71.2 | Adapted from [38,39] | |
2–4 | 68.1 | 52.0 | 48.0 | 0.0 | 67.3 | 68.9 | ||
5–8 | 61.0 | 52.0 | 48.0 | 0.0 | 60.2 | 61.8 | ||
9–17 | 52.9 | 52.0 | 48.0 | 0.0 | 52.1 | 53.7 | ||
18–49 | 32.3 | 2.0 | 97.0 | 1.0 | 31.9 | 32.7 | ||
50–64 | 45.3 | 0.0 | 99.0 | 1.0 | 44.9 | 45.7 | ||
65–106 | 65.0 | 0.0 | 100.0 | 0.0 | 64.6 | 65.4 | ||
LAIV contraindications by age, years | ||||||||
2–4 | 8.8 | [40] | ||||||
5–17 | 1.0 | |||||||
Absolute vaccine coverage increases with choice | 6.5 | 3.25 | 11.25 | [1] | ||||
Vaccine cost, US$ | ||||||||
IIV-IM | 10.69 | 0.00 | 21.38 | [41] | ||||
LAIV | 23.70 | 0.00 | 47.40 | |||||
IIV-ID | 15.69 | 0.00 | 31.38 | |||||
Vaccine administration cost, US$ | 25.08 | [28] | ||||||
Increased cost of choice | 5.0 | 2.5 | 7.5 | [42] | ||||
Latent period, daysa | 1.9 | 1 | 2 | [17,20–25,43] | ||||
Infectious period, daysa | 4.1 | 3 | 6 | |||||
Asymptomatic rateb | 33.0 | |||||||
Asymptomatic reduction in infectivityc | 50.0 | |||||||
Symptomatic absenteeismb | 50.0 | |||||||
Vaccine effectivenessb | 59.0 | [44] |
IIV = inactivated influenza vaccine; LAIV = live attenuated influenza vaccine; IM = intramuscular; ID = intradermal.
Drawn from a truncated Weibull distribution with the listed nominal (mean), minimum and maximum values.
Probability point estimate that does not vary across simulations; within each simulation, it is the action potential threshold above which an outcome (i.e., exhibit symptoms, stay home from work, or vaccine protects against disease) occurs and below which it does not.
A constant that does not vary across simulations.