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Gene-gene regulatory networks constructed from the gene expression profiles for (A) neoadjuvant docetaxel resistive samples and (B) neoadjuvant docetaxel sensitive samples after incorporation of biological prior knowledge from the MAPK signaling pathway. Active and inactive genes are highlighted in gray and white, respectively. The domains of connectivity are delineated by a dashed line in each network and genes with vertex connectivity greater than 4 are highlighted in blue.
