Fig 6. Parameter estimates under growth factor perturbation suggest that the highly-variable (H) phase is growth factor sensitive.

(A) MCF10A cells in DMSO control vs. treatment with the EGFR inhibitor erlotinib; (B) MCF10A wild-type (WT) cells vs. MCF10AT1 cells (indicated by V12-Ras). p-values were calculated using a two-sample bootstrapping scheme (see “Parameter estimation and model selection”). Blue signifies unperturbed; red signifies perturbed.