Table 4. Synonymous changes, including replacements from donors and new mutations, in recombinant genomes after 1000 generations of the STLE.
| Population (Clone) | Recombined synonymous replacements |
Synonymous mutations in recipient-derived segments | Synonymous mutations in donor-derived segments | Recombined / mutated synonymous changes |
|---|---|---|---|---|
| Ara+1 (REL11734) |
8788 | 2 | 2 | 2197–4394 |
| Ara+1 (REL11735) | 8766 | 2 | 2 | 2191.5–4383 |
| Ara+2 (REL11736) |
0 | 0 | 0 | ND |
| Ara+2 (REL11737) | 0 | 1 | 0 | 0.0 |
| Ara+3* (REL11738) | 1 | 13 | 0 | 0.08 |
| Ara+3* (REL11739) | 1369 | 18 | 1 | 72.1–76.1 |
| Ara+4 (REL11740) | 5228 | 0 | 1 | 5228 –ND |
| Ara+4 (REL11741) | 3135 | 0 | 0 | ND |
| Ara+5 (REL11742) | 3648 | 0 | 0 | ND |
| Ara+5 (REL11743) | 3670 | 0 | 0 | ND |
| Ara+6* (REL11744) | 659 | 9 | 0 | 73.2 |
| Ara+6* (REL11745) | 656 | 7 | 0 | 93.7 |
| Ara–1 (REL11746) |
5839 | 3 | 1 | 1459.7–1946.3 |
| Ara–1 (REL11747) |
5825 | 0 | 1 | 5825 –ND |
| Ara–2* (REL11748) | 1142 | 13 | 0 | 87.8 |
| Ara–2* (REL11749) |
1141 | 10 | 3 | 87.8–114.1 |
| Ara–3 (REL11750) |
23396 | 3 | 2 | 4679.2–7798.7 |
| Ara–3 (REL11751) |
23454 | 0 | 2 | 11727 –ND |
| Ara–4 (REL11752) |
3749 | 0 | 0 | ND |
| Ara–4 (REL11753) |
3730 | 1 | 0 | 3730 |
| Ara–5 (REL11754) |
7852 | 2 | 2 | 1963–3926 |
| Ara–5 (REL11755) |
6415 | 1 | 0 | 6415 |
| Ara–6 (REL11756) |
3197 | 2 | 0 | 1598.5 |
| Ara–6 (REL11757) |
0 | 0 | 0 | ND |
Note: Ratios of recombined to mutated synonymous changes are calculated with (lower bound) and without (upper bound) synonymous mutations in donor-derived segments. Only one value is shown when there were no synonymous mutations in the donor-derived segments. ND indicates a ratio is not defined because its denominator equals zero. Hypermutator clones are marked with an asterisk.