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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Methods Enzymol. 2017 Jul 14;593:405–448. doi: 10.1016/bs.mie.2017.05.005

Figure 14.

Figure 14

CM results for the GPR3-TMH6 study to identify a TMH6 conformer appropriate for a GPR3 activated state model of G-protein dependent signaling. A) Intracellular view of the bundle; B) Lipid view. Conformers have been superimposed at their extracellular ends. The magenta TMH6 corresponds to TMH6 in our GPR3 inactive state model. In green, some of the free energy conformers obtained from CM. Other TMHs in the bundle are colored in steel blue. The chosen TMH6 for the GPR3 active state model (R*) is highlighted in yellow.