Skip to main content
. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Methods Enzymol. 2017 Jul 14;593:405–448. doi: 10.1016/bs.mie.2017.05.005

Figure 7.

Figure 7

CM results for the GPR3-TMH7 study of possible helix deformation created by P7.41. A) Extracellular view of the bundle; B) Lipid view. Conformers have been superimposed at their intracellular ends. The magenta TMH7 corresponds to the S1PR1 crystal structure that was mutated to the GPR3 sequence. In green, some of the low free energy conformers obtained from CM are illustrated. Other TMHs in the bundle are colored in steel blue. The chosen TMH7 for the GPR3 homology model is highlighted in yellow.