. Author manuscript; available in PMC: 2018 Feb 12.

Published in final edited form as: Methods Enzymol. 2017 Jul 14;593:405–448. doi: 10.1016/bs.mie.2017.05.005

Table 1.

Comparison of GPR3 sequence with that of GPR6, GPR12, S1PR1, LPAR1, CB1, CB2, Rho, β2-AR, μ-OR, GPR55 and GPR18.

GPR3 compared to the following Class A GPCRs	SS	SI	SS	SI
GPR3 compared to the following Class A GPCRs	TMH	TMH	Full seq.	Full seq.
GPR6	78	64	65	53
GPR12	80	63	68	53
S1PR1^*^#	50	28	39	20
LPAR1^*^#	50	30	38	21
CB1^*	43	27	27	16
CB2	44	27	33	19
Rho^*	38	18	29	13
β2-AR^*	36	19	28	15
μ-OR^*	36	17	26	13
GPR55	33	16	26	12
GPR18	32	15	25	11

Data obtained from GPCRdb.org

% Sequence similarity (SS) and % sequence identity (SI) with GPR3 when considering the full sequence or at a transmembrane level.

Crystallized GPCRs.

Highest percentage of sequence homology among crystal structures [PDB ID codes: 3V2Y (S1PR1), 4Z35 (LPAR1)].