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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Acta Biomater. 2017 Jan 6;50:428–436. doi: 10.1016/j.actbio.2017.01.010

Figure 1. Schematic illustration of microcapsule fabrication process.

Figure 1

A) Microfluidic flow-focusing device is infused with two aqueous streams one containing cell suspension, another carrying 4-arm PEG-maleimide (PEG4MAL). These aqueous streams experience minimal mixing due to differences in viscosity. Core-shell particle patterning is achieved by generating coaxial flow (see cross-section) upstream of flow-focusing junction. Emulsification occurs by exposure to two oil streams, the first one designed to stabilize aqueous droplets the second one to deliver a crosslinker DTT to gel PEG4MAL.