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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Microcirculation. 2018 Feb;25(2):10.1111/micc.12429. doi: 10.1111/micc.12429

Figure 5.

Figure 5

Impact of SKCa/IKCa activation on endothelial membrane potential and membrane resistance predicted by the isolated EC model.17 (a) Predicted Vm during direct maximum (100%) opening of SKCa/IKCa (NS309) followed by application of ACh (2 a.u.). To determine Rm at individual time points, current pulses were applied periodically (±0.4 pA for 2 s every 30 s), whereby the ratio of the resulting ΔVm to the injected current corresponded to Rm. (b) Predicted changes in Rm (defined as ΔVm/Istim) show ~80% drop during direct SKCa/IKCa opening with NS309 and during indirect SKCa/IKCa opening with ACh (from Rm = 11.5 GΩ to Rm = 2.4 GΩ). [Ca2+] transient and corresponding changes in channel conductance (G) during the stimulations are shown in (c) and (d).