Table 1.
Multivariate Cox regression models for OS, DSS, and MFS
| Characteristic | OS (n = 388; 120 events) | DSS (n = 388; 118 events) | MFS (n = 289; 114 events) | |||
|---|---|---|---|---|---|---|
|
| ||||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| TERT alteration | 2.31 (1.46–3.65) | <0.001 | 2.23 (1.41–3.53) | <0.001 | 1.63 (1.05–2.53) | 0.029 |
| Mutational burden/Mb | 0.96 (0.93–0.99) | 0.002 | 0.96 (0.93–0.99) | 0.002 | 0.98 (0.96–1.00) | 0.063 |
| Age | 1.02 (1.01–1.04) | 0.012 | 1.02 (1.01–1.04) | 0.013 | 1.02 (1.00–1.04) | 0.016 |
| Tumor stage | ||||||
| NMIBC | Reference | Reference | Reference | |||
| MIBC | 16.77 (7.11–39.55) | <0.001 | 23.95 (8.93–64.23) | <0.001 | 11.35 (6.21–20.74) | <0.001 |
| Localized UTUC | 11.85 (4.68–30.02) | <0.001 | 16.03 (5.64–45.54) | <0.001 | 8.93 (4.79–16.66) | <0.001 |
| Metastatic | 56.09 (23.57–133.47) | <0.001 | 74.26 (27.57–200.02) | <0.001 | – | – |
| Variant histology | 1.54 (1.02–2.33) | 0.040 | 1.52 (1.01–2.31) | 0.047 | 1.77 (1.40–2.75) | 0.011 |
OS = overall survival; DSS = disease-specific survival; MFS = metastasis-free survival; HR = hazard ratio; CI = confidence interval; NMIBC = non–muscle-invasive bladder cancer; MIBC = muscle-invasive bladder cancer;