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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: J Immunol. 2018 Jan 19;200(4):1261–1269. doi: 10.4049/jimmunol.1700562

Figure 4. Effects of Monocyte Depletion and Migration Blockade on Allergen-Induced AHR and Airway Inflammation.

Figure 4

OVA sensitized and challenged mice (n=8 per group) received a single i.v. injection of MSC. Monocytes were concurrently depleted in one group of mice by i.v. administration of liposomal clodronate (OVA/OVA+MSC+Lip Clod) or vehicle alone (OVA/OVA+MSC+Vehicle). Liposomal clodronate was injected by i.p. 24 hours prior to and following MSC injection. The effects of liposomal clodronate administration on MSC-induced suppression of (A) AHR, (B) eosinophil numbers in BAL fluid, and (C) goblet cell metaplasia along the airways were assessed (*p<0.05).