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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: J Immunol. 2018 Jan 19;200(4):1261–1269. doi: 10.4049/jimmunol.1700562

Figure 5. The Role of CCL2-CCR2 Axis for MSC-Induced Suppression of Allergen-Induced AHR and Airway Inflammation.

Figure 5

OVA sensitized and challenged mice (n=8 per group) received MSC treated with CCR2 antagonist RS102895 (OVA/OVA+MSC+RS102895) or vehicle alone (OVA/OVA+MSC+Vehicle). (A) AHR and (B) eosinophil numbers in BAL fluid were assessed (*p<0.05). To identify the source of CCL2, MSC were derived from CCL2−/− mice (CCL2−/− MSC) and the effects of administration into WT mice (OVA/OVA+CCL2−/− MSC) on (C) AHR and (D) eosinophil numbers in BAL fluid were compared to recipients of WT MSC (OVA/OVA+WT MSC) (n=8 per group) (*p<0.05).