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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: J Immunol. 2018 Jan 12;200(4):1457–1470. doi: 10.4049/jimmunol.1701248

Figure 3. B. burgdorferi infection results in universal expansion and activation of CD4+ and CD8+ T cells.

Figure 3

IL-10−/− mice were infected with B. burgdorferi for 4 weeks, after which popliteal and inguinal lymph nodes were collected for analysis of TCR repertoires. (A) and (B) Frequency of TCR Vβ-specific cells was quantified for CD3+CD4+ (upper panel) or CD3+CD8+ (lower panel) gated populations. (C) and (D) Frequency of TCR Vβ-specific cells was quantified for CD4+IFN-γ+ (upper panel) and CD8+IFN-γ+ (lower panel) gated populations. Error bars indicate the SEM (n≥3 per group). Data are representative of two independent experiments.