Skip to main content
. 2017 Oct;187(10):2323–2336. doi: 10.1016/j.ajpath.2017.06.011

Figure 6.

Figure 6

Plasma cytokine concentrations are reduced by histidine decarboxylase (Hdc)A-positive Lactobacillus reuteri. Wild-type L. reuteri 6475 administration significantly decreases the abundances of proinflammatory cytokines keratinocyte chemoattractant (KC) (A), IL-22 (B), and IL-6 (C) in Hdc−/− mouse plasma determined by Luminex assays, whereas the isogenic L. reuteri hdcA mutant that lacks the histamine-producing capacity lacks such effects. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. AOM, azoxymethane; DSS, dextran sulfate sodium; MRS, deMan, Rogosa, Sharpe; PBS, phosphate-buffered saline.