Table 3.
Pregnancy outcomes and neonatal characteristics. Metformin study from European Teratology Information Services (TIS) 1993–2015
| Characteristic | Metformin group (n = 458) | Reference group (n = 479) |
|---|---|---|
| SAB, n | 49 | 29 |
| ETOP, n (%) | 9 (2) | 20 (4) |
| MTOP, n (%) | 12 (3) | 3 (<1) |
| Stillbirths, n (%) | 9 (2) | 6 (1) |
| Live births, n (%) | 379 (83) | 421 (88) |
| Among | Metformin live birth (n = 379) | Reference live birth (n = 421) |
|---|---|---|
| Gestational wk at birth | ||
| Missing, n (%) | 7 (2) | 7 (2) |
| Median (min‐max) [wk] | 38 (25–42) | 39 (27–42) |
| Preterm (<37 wk), n (%) | 71 (19) | 25 (6) |
| Sex, n (%) | ||
| Missing | 12 (3) | 13 (3) |
| Female | 190 (50) | 232 (56) |
| Birth weight a | ||
| Missing, n (%) | 16 (4) | 15 (4) |
| Median (min‐max) [g] | 3300 (740–5130) | 3300 (540–4785) |
| LBW, n (%) | 50 (13) | 30 (8) |
| Macrosomia, n (%) | 14 (4) | 2 (<1) |
| Delivery mode, n (%) | ||
| Missing | 15 (4) | 16 (4) |
| Vaginal deliveries | 131 (35) | 251 (62) |
| Assisted deliveries | 235 (62) | 152 (38) |
SAB, spontaneous abortion; ETOP, elective termination of pregnancy; MTOP, medical termination of pregnancy; LBW, low birth weight.
a
Not restricted to full term