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Minimal physiologically based pharmacokinetic model used to predict the pharmacokinetics of olanzapine. CLH, hepatic clearance; CLR, renal clearance; fa, fraction absorbed; 1 – fa, fraction excreted unchanged in the faeces; FG, fraction escaping gastrointestinal metabolism; 1 – FG, fraction metabolized in the gut; FH, fraction escaping hepatic metabolism
