Table 1.
Demographic data of the paediatric and adult groups for population pharmacokinetic model development. The paediatric group is further divided into neonates and children with subjects in the Neonate Study and the Children Study, respectively. Data are presented as median (range)
| Paediatric group (n = 17) | Adult group (n = 9) | ||
|---|---|---|---|
| Neonates (n = 7) | Children (n = 10) | ||
| Age (years) | 0.11 (0.060–0.41) | 5 (2–15) | 19 (15–47) |
| Weight (kg) | 6.25 (3.92–6.60) | 21.0 (11.8–69.2) | 69.1 (58.2–130) |
| Creatinine clearance (ml min −1 1.73 m −2 ) | 80.0 (60.0–122) | 108 (85.3–127) | 107 (85.0–113) |
| Gender | |||
| Female | 4 | 4 | 6 |
| Male | 3 | 6 | 3 |
| Race | |||
| Caucasian | 6 | 9 | 9 |
| Others | 1 (unknown) | 1 (unknown) | 0 |
| Number of exendin‐(9‐39) plasma levels | 34 | 67 | 81 |