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Increased gene expression (A) and activity (B) of cytochrome P450 (CYP) 3A4, CYP2C9 and CYP2B6 caused by dicloxacillin treatment of human hepatocytes (mean of four donors). Data are shown as mean fold increase relative to vehicle (0.1% dimethyl sulfoxide) with standard deviations. Solid and dashed lines represent average (Css, avg), minimum (Css, min) and maximum concentration of dicloxacillin (Css, max) at steady state at 500 mg dicloxacillin four times daily in healthy volunteers 4
