Figure 6.

Nuclear receptor activity relative to vehicle induced by dicloxacillin (A) and flucloxacillin (B). AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; PXR, pregnane X receptor. Data are shown as mean fold‐increase relative to vehicle (0.1% dimethyl sulfoxide) with standard deviations. Solid and dashed lines for dicloxacillin represent average (C_{ss, avg}), minimum (C_{ss, min}) and maximum concentration of dicloxacillin (C_{ss, max}) at steady state at 500 mg dicloxacillin four times daily in healthy volunteers 4, while the solid line for flucloxacillin represents the maximum plasma concentration after a 750 mg single dose of flucloxacillin in healthy volunteers 3