Table 2.
Thickness | ||||||
---|---|---|---|---|---|---|
GCL | IPL | INL | OPL | ONL | Total | |
Sham before | 19.86 ± 0.95 | 46.33 ± 1.38 | 22.13 ± 1.19 | 16.97 ± 1.14 | 69.27 ± 2.65 | 174.58 ± 4.26 |
Sham after | 20.90 ± 1.36 | 46.32 ± 1.50 | 20.93 ± 1.50 | 15.93 ± 0.91 | 65.52 ± 2.32 | 169.60 ± 4.42 |
ICP before | 21.88 ± 1.31 | 46.06 ± 1.89 | 19.63 ± 1.10 | 16.74 ± 1.12 | 59.02 ± 2.23 | 163.33 ± 3.00 |
ICP after | 18.97 ± 0.87 | 50.35 ± 2.41 | 19.64 ± 1.53 | 19.12 ± 1.03 | 56.45 ± 2.44 | 164.54 ± 3.48 |
Thickness values are expressed as mean µM ± SEM. N = 6 eyes in each group. For each eye, SD-OCT was used to calculate the thickness of each retinal layer at the start of the experiment (Sham before and ICP before). This was compared to the thickness of each layer in the same eye after 2 weeks (Sham after and ICP after) with a t-test. The only difference detected in any retinal layer was a reduction in the thickness of the GCL after 2 weeks of ICP elevation (bold, p = 0.037). SD-OCT = Spectral domain optical coherence tomography; ICP = intracranial pressure; GCL = retinal ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer.