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. 2018 Feb 12;8:2785. doi: 10.1038/s41598-018-20973-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD44v is highly expressed in pancreatic islets of diabetic mice. (A) Immunohistochemical staining of CD44 (panCD44) and CD44v in the stomach, intestine, pancreas, liver, lung, and adipose tissue of adult C57BL/6 mice. Scale bars, 50 µm. (B) Immunohistochemical staining of panCD44 and CD44v in pancreatic islets of adult db/db, ob/ob, and Akita diabetic mice and the corresponding WT animals. Scale bars, 50 µm. (C) Immunohistofluorescence staining of CD44v and insulin in pancreatic islets of adult db/db, ob/ob, and Akita diabetic mice and the corresponding WT animals. The fluorescence (blue) of nuclei counterstained with 4′,6-diamidino-2-phenylindole (DAPI) is shown in the merged images. Scale bars, 40 µm.