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Model of PANDAR involved in splicing regulation. At normal and low PANDAR level, PTBP1 is involved in splicing of the BCL-XS short isoform resulting in its upregulation and pro-apoptotic cellular outcome (left). Upon PANDAR upregulation, PANDAR is bound to PTBP1 and functions as a decoy resulting in a decreased level of BCL-XS splice variant leading to a reduced level of pro-apoptotic response (right). Red ribbon: schematic representation of PANDAR.
