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. 2018 Feb 12;8:2788. doi: 10.1038/s41598-018-21021-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thrombin Substrate motif. (A) Schematic overview for alignment of peptides assuming Arg as P1. For peptides containing multiple Arg residues, the center-most Arg was aligned, with preference given to position 3 Arg residues in peptides containing Arg residues at position 3 and 4. (B) The iceLogo plot representing the relative frequency of every amino acid in the cleaved (top) and uncleaved (bottom) peptide pools following thrombin selection. (C) The iceLogo heatmap shows the preference for each amino acid at every position in the cleaved (green) or uncleaved (red) peptide pools. Residues at positions that do not appreciably populate either pool are also indicated (black).