. 2018 Feb 8;9:181. doi: 10.3389/fimmu.2018.00181

Table 1.

Protection against Borrelia burgdorferi in mice passively immunized with serum raised from CspZ- or virus-like particle (VLP)-immunized mice.

Immunogen	No. of tissue culture positive/total^a					No. of mice protected/total^a^,^b	p-Value^c
Immunogen	Inoc. site	Bladder	Heart	Joint	Ear	No. of mice protected/total^a^,^b	p-Value^c
Preimmune serum	6/6	6/6	6/6	6/6	6/6	0/6
VLP	6/6	6/6	6/6	6/6	5/6	0/6	1.00
CspZ	6/6	5/6	6/6	4/6	4/6	0/6	1.00
VLP-CspZ	4/6	4/6	4/6	4/6	4/6	2/6	0.22
VLP-CspZ-Y207A/Y211A	0/6	0/6	0/6	0/6	0/6	6/6	0.002

^aCombined two trials.

^bMice were considered infected (not protected) when at least one culture was positive.

^cOne-tailed Fisher Exact Probability Test, Compared to the mice inoculated with pre-immune mouse serum.