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. 2018 Feb 8;12:58. doi: 10.3389/fnins.2018.00058

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Copyright © 2018 Salech, Ponce, SanMartín, Rogers, Henríquez and Behrens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H₂O₂-induced death of lymphocytes from cancer, cancer & AD and healthy controls. Lymphocytes from 11 cancer patients (Ca; green symbols), 13 cancer & AD (Ca&AD; purple symbols) patients, and 12 healthy controls (HC; black symbols) were exposed to different concentrations of H₂O₂ for 20 h and death was determined by flow cytometry with propidium iodide staining. (A) Lymphocyte survival curve at increasing concentrations of H₂O₂; (B) Survival values at 20 μM H₂O₂; (C,D) apoptosis and necrosis curves, respectively, from experiments in A (%, means ± SE). The results previously reported (Salech et al., 2017) on AD lymphocytes were added in A and B for comparison. ^xCa vs. HC, ^*Ca&AD vs. HC. 1 symbol: p < 0.05; 2 symbols: p < 0.005; 3 symbols: p < 0.0001 for all figures.