Fig. 2.

Mesenchymal IKK2-dependent signals promote arthritic manifestations in TNF-mediated arthritis. a Representative histological images of H&E, Toluidine Blue (TB) and Tartrate-Resistance Acid Phosphatase (TRAP) stained ankle joint sections and histological score of synovial hyperplasia, cartilage destruction and bone erosion of hTNFtg Ikk2^f/f and hTNFtg Ikk2^Ms-KO mice (n = 10; age: 11 weeks). b Representative histological images of H&E-, TB- and TRAP-stained ankle joint sections and histological score of synovial hyperplasia, cartilage destruction and bone erosion of Ikk2^f/f (n = 7) and Ikk2^Ms-KO mice (n = 8) subjected to CAIA at the peak of disease (Day 8). (3 experiments, n = 20–22 mice per genotype). Scale bar: 100 and 50 μm. Data are presented as the mean ± SEM. **P < 0.01 and ***P < 0.001, by two-tailed Student’s t-test