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. 2018 Feb 8;9:53. doi: 10.3389/fphar.2018.00053

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Copyright © 2018 Dou, Miao, Wang, Chen, Wang, Chen, Wen and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Masson staining and Western blot analysis of kidney tissue. (A) Representative images of Masson stained kidney sections from control, adenine-induced CKD and CKD+AO groups. (B) Immunohistochemical findings with anti-Fibronectin, α-SMA and Collagen I antibodies in the control, adenine-induced CKD and CKD+AO groups of rat kidneys. (C) Protein expression of PAI-1, α-SMA, and collagen I in the renal tissues of control, adenine-induced CKD and CKD+AO groups. ^**p < 0.01 compared with control group; ^##p < 0.01 compared with CKD group. The data are presented as the mean ± SD (n = 8 in each group).