Figure 9.

Lipid metabolic pathway analysis of identified differential lipid species. (A) Summary of IPA with MetPA including glycerophospholipid metabolism, arachidonic acid metabolism, biosynthesis of unsaturated fatty acids, linoleic acid metabolism, α-linolenic acid metabolism, and glycosylphosphatidylinositol (GPI)-anchor biosynthesis from significantly different lipid species. The size and color of each circle is based on pathway impact values and p-values, respectively. (B) Overview of glycerophospholipid metabolism with MetPA (reference map by KEGG). Green boxes represent enzymatic activities with putative cases of analogous activities in rats. (C) Lipid metabolic networks were constructed by using Wikipathways, Signalink, SMPDB, Reactome, PhosphoSitePlus, NetPath and MatrixDB. Adenine-induced CKD were associated with glycerophospholipid metabolism, triacylglycerol degradation, fatty acid activity, arachidonic acid metabolism and metabolism of lipids and lipoproteins.