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. 2018 Feb 12;8:2821. doi: 10.1038/s41598-018-21121-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of hepatocyte differentiation of organoids derived from surgically resected IHCC tissues. Organoids were established using surgically resected tissues of poorly to moderately differentiated IHCC from patient #2 (a) and moderately differentiated IHCC from patient #3 (b). H&E and CK19 staining of the primary tissues and organoids derived from IHCC cases (scale bars: 100 μm) and bright-field images of IHCC organoids (scale bars: 1000 μm) are shown. After stable culture over 10 passages, these IHCC organoids were subjected to hepatocyte differentiation using the same protocol, and the relative expression of Albumin (ALB) and CYP3A4 in organoids that had been cultured in EM or DM were examined.