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. 2018 Feb 8;11:24. doi: 10.3389/fnmol.2018.00024

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Copyright © 2018 Chen, Chi, Kang, Liu, Zhang, Li, Zhao, Yang, Su, Cai, Liao, Yi, Wan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanical allodynia and sensitization of uninjured sural nerve fibers in spared nerve injury (SNI) rats. (A) Mechanical allodynia in SNI rats 3–21 days after nerve injury. ***p < 0.001, two-way analysis of variance (ANOVA) with Bonferroni post hoc test, n = 8–9. (B) The CV of Aδ-fibers, but not Aβ-fibers and C-fibers was increased in SNI rats. **p < 0.01, unpaired t tests. (C) Mechanical thresholds of Aβ-, Aδ- and C-fibers were decreased in SNI rats. *p < 0.05, ***p < 0.001, unpaired t tests. (D) Receptive field areas of Aβ-, Aδ- and C-fibers were increased in SNI rats. *p < 0.05, ***p < 0.001, unpaired t tests.