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. 2018 Feb 8;11:24. doi: 10.3389/fnmol.2018.00024

Figure 5.

Figure 5

Mibefradil, a T-type calcium channel blocker, decreased mechanical thresholds of Aβ-, Aδ- and C-fibers in SNI rats. (A) Mibefradil (0.01, 0.10 and 1.0 mM, 10 μl) dose-dependently increased mechanical thresholds of Aβ-fibers in SNI rats. **p < 0.01, Kruskal-Wallis H-test, n = 6 –15. (B) Mibefradil (1.0 mM, 10 μl) had no effect on the mechanical thresholds of Aβ-fibers in Sham-operation rats. n = 12–13. (C) Mibefradil (0.01, 0.10 and 1.0 mM, 10 μl) dose-dependently increased mechanical thresholds of Aδ-fibers in SNI rats. *p < 0.05, ***p = 0.001, Kruskal-Wallis H-test, n = 8–13. (D) Mibefradil (1.0 mM, 10 μl) had no effect on mechanical thresholds of Aδ-fibers in Sham-operation rats. n = 10–12. (E) Mibefradil (1.0 mM, 10 μl) increased mechanical thresholds of C-fibers in SNI rats. *p < 0.05, Mann-Whitney U-test, n = 8–11. (F) Mibefradil (1.0 mM, 10 μl) had no obvious effect on mechanical thresholds of C-fibers in Sham-operation rats. n = 10–14.